27 September 2023

Koala mums pass on deadly virus

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Dominic Jarvis* says a new study from the University of Queensland has found mother koalas are transferring a deadly virus, called koala retrovirus, to their joeys.


The virus can cause immune depletion and cancer.

It also predisposes koalas to chlamydia and other diseases and was having a large effect on wild koala populations across Queensland and New South Wales, says Keith Chappell, associate professor at the University of Queensland’s School of Chemistry and Molecular Biosciences.

“Koala retrovirus—also known as KoRV—and associated diseases are another threat facing koalas, along with climate change and habitat loss.

“The virus causes immune depletion, likely making it much harder for koalas to cope with these other, already-detrimental environmental stressors,” he says.

“All northern koalas share a single highly conserved version of KoRV that is integrated into the koala genome, however until now, we weren’t certain how other disease-causing variants are spread.

“By sequencing variations of the virus DNA in 109 captive koalas, we finally revealed how the virus spreads—from mother to joey,” Chappell says.

“It seems that transmission between mother and joey likely occurs due to close proximity, via a joey’s exposure to a mother’s potentially infectious fluids, like their milk.

“Mothers were sharing their virus variants three times more than fathers, suggesting this is the dominant pathway of spread for the virus.

“And, unlike other diseases affecting koalas like chlamydia, there’s no evidence of sexual transmission.”

The 109 koalas were housed in two sites in southeast Queensland, helping identify a total of 421 unique koala retrovirus sequences.

The research may lead to a re-think in how conservation plans are executed, says Briony Joyce, a PhD candidate and lead author of the paper in the Proceedings of the National Academy of Sciences.

“This work will be highly informative for koala conservation, as it suggests that captive breeding programs focused on mothers that have a low amount of retrovirus variants, could result in healthier animals for release,” Joyce says.

“Also, we propose that antiretroviral treatment—if shown to be safe in koala and effective against KoRV—could be used specifically in mothers during breeding seasons to prevent transmission.

“This work helps pave the way for evidence-based conservation, increasing koala resilience to help them cope with a changing and challenging environment.

“We must do everything we can to ensure the survival of this culturally important species.”

*Dominic Jarvis is a contributor for UQ News.

This article first appeared at uq.edu.au.

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